Interactions of Magainin-2 Amide with Membrane Lipids
نویسندگان
چکیده
Magainin-2 is a natural peptide that kills bacteria at concentrations that are harmless to animal cells. Molecular modelling methods were applied to investigate basic mechanisms of magainin-2 amide (M2a) membrane selectivity. Three computer models of a lipid matrix of either animal or bacterial membrane containing M2a were constructed and simulated. Specific interactions between membrane lipids and M2a peptides, responsible for M2a selectivity are elucidated.
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تاریخ انتشار 2004